Studying of lipophilicity of potential biological active cyanoacetamide derivatives

Abstract

By applying the Lipinski’s rule for selected cyanoacetamide derivatives the possible existence of biological activity is theoretically investigated. Alos,using appropriate software packages and applying reverse-phase thin-layer chromatography (RP TLC18 F_254s) in water-t-butanol, water-dimethylformamide and water-dimethylsulfoxide the lipophilicity of the studied cyanoacetamides was determined. Chromatographic retention parameters, RM⁰ and m, as presumed criteria of lipophilicity of examined cyanoacetamides were correlated by linear regression analysis with standard measure of lipophilicity, log P, with important pharmacokinetic predictors and selected parameters of toxicity. The established linear dependences are described by high regression coefficient values, r, which showed that RP TLC18 F_254s allows reliable determination of the lipophilicity of cyanoacetamides as potentially bioactive compounds.