CHROMATOGRAPHIC BEHAVIOR AND LIPOPHILICITY OF N-(4-PHENYLSUBSTITUTED)-2,3-DIPHENYLPROPANAMIDES

Dj.  Vastag; N.  Perišić -Janjić; S.  Apostolov; S.  Petrovic

CHROMATOGRAPHIC BEHAVIOR AND LIPOPHILICITY OF N-(4-PHENYLSUBSTITUTED)-2,3-DIPHENYLPROPANAMIDES

Authors

Dj. Vastag Department of Chemistry, Biochemistry and Enviromental Protection, Faculty of Science, University of Novi Sad, Trg D. Obradovića 3, Novi Sad
N. Perišić -Janjić Department of Chemistry, Biochemistry and Enviromental Protection, Faculty of Science, University of Novi Sad, Trg D. Obradovića 3, Novi Sad
S. Apostolov Department of Chemistry, Biochemistry and Enviromental Protection, Faculty of Science, University of Novi Sad, Trg D. Obradovića 3, Novi Sad
S. Petrovic Faculty of Technology and Metallurgy, Karnegijeva 4, Beograd

Keywords:

Chromatography, Compound, Structure

Abstract

Retention behavior of some N-(4-phenylsubstituted)-2,3-diphenylpropanamides was investigated on reversed phase thin layer chromatography (RP-C₁₈). Retention constants of investigated compounds were determined in the following solvent systems: water-ethanol, watern-propanol and water-i-propanol. Linear relationships were obtained between retention, RM and volume fraction of organic solvent, ϕ. As a measure of lipophilicity of tested propanamides, Hansch`s lipophilicity parameter, π, were calculated. Chromatography retention constants RM⁰ were correlated with Hansch`s lipophilicity parameter, and good linear relationships were obtained. These results confirm, that retention constants, (RM⁰ ), determined in reversed phase thin-layer chromatography (RP-TCL) can be used, as criteria of lipophilicity.

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Published

2011-12-30

How to Cite

Vastag, D. ., Perišić -Janjić, N. ., Apostolov, S. ., & Petrovic, S. . (2011). CHROMATOGRAPHIC BEHAVIOR AND LIPOPHILICITY OF N-(4-PHENYLSUBSTITUTED)-2,3-DIPHENYLPROPANAMIDES. Journal of Engineering &Amp; Processing Management, 3(1), 7–15. Retrieved from http://jepm2021.tfzv.ues.rs.ba/index.php/pub/article/view/57